Please enable JavaScript.

Coggle requires JavaScript to display documents.

Aetiology of disease (Acquired (10) (Environmental factors (Contributory…

- - - - DNA expression error/may have environmental cause
        
        Rubella virus infection
        
        Thalidomide phocomelia
        
        Heart defects
    - - Involves many genes may have environmental influence
        
        Hypertension : A set of genes predisposes one to hypertension. Environmental factors such as salt intake and stress increase BP.
    - - Gene defects
        
        Phenylketonuria (PKU) Enzyme gene defect leads to abnormal metabolism of phenylalanine
        Diagnosed at birth with Guthrie test
        Dietary modification throughout life
        
        Toxicity, neurological deficit, rigidity, sandy
        hair, eczema-like skin lesions
    - - Chromosomal defects (structure/ number)
        
        KLINEFELTER’S
        SYNDROME (47, XXY)
        
        Downs Syndrome (47, XY+21)