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Interstitial Lung Disease (Pathophysiology (Chronic inflammation,…
Interstitial Lung Disease
Definition
Generic term used to describe conditions that affect the lung parenchyma diffusely
Pathophysiology
Chronic inflammation
Hyperplasia of type II epithelial cells or type II pneumocytes
Fibrosis and remodelling of interstitium
Signs
Non productive paroxsymal cough
Abnormal breath sounds
Dyspnoea on exertion
Investigations
Abnormal CT
Spirometry: restrictive
Abnormal chest x-ray
Classification
Systemic
RA
SLE
Sarcoidosis
UC
Idiopathic
Idiopathic pulmonary fibrosis
Known Cause
Hypersensitivity
Infection
Drugs
GORD
Occupational