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ACUTE ASTHMA EXACERBATION (Clinical Presentation (Tachycardia, Tachypnea,…
ACUTE ASTHMA EXACERBATION
Diagnosis
Increased PaCO2
Response to SABA
History of allergies
Family History
Treatment
Maintainance Inhaled Corticosteriod
Step-up Therapy
Short course of oral corticosteriods
Short-acting Beta Agonist
Clinical Presentation
Tachycardia
Tachypnea
Wheeze
Chest Tightness
Cough
cyanosis
Epidemiology
Exogenous Irritant/Smoke
Chemical Irritant
Acute Viral Infection
Age
Gender
Pathophysiology
Allergen triggers T-helper 2 cells
Interlukins released
chemotaxis of eosinophils
Late Stage Reaction
Edema
Deceased Airflow
Broncospasm
Mucus secretion
B lymphcytes produce IgE antigens
IgE activates to mast cells
allergen binds to mast cell, histamine is released
Bronchospasm
Decreased Airflow
4 to 8 hour time lapse
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Inflammatory cytokines released
edema
vasodilation