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HYPOPITUITARISM (CLINICAL MANIFESTATIONS (anorexia and weight gain or loss…
HYPOPITUITARISM
CLINICAL MANIFESTATIONS
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stiff joints, poor response to stress
CAUSES
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Partial or total hypophysectomy by surgery, irradiation, or chemical agents
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COMPLICATIONS
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High fever, shock, coma, and death
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PATHOPHYSIOLOGY
The pituitary gland is extremely vulnerable to ischemia and infarction because it's highly vascular.
Any event that leads to circulatory collapse and compensatory vasospasm may result in gland ischemia, tissue necrosis, or edema.
Expansion of the pituitary within the fixed compartment of the sella turcica further impedes blood supply to the pituitary.
Impaired function of the pituitary gland in turn leads to reduced hormone production by the target glands.
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DEFINITION
Endocrine deficiency in which any of the hormones produced by the anterior portion of the pituitary gland are secreted at inefficient levels or are absent