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Micro - Antibiotics MOAs (Cell wall active agents (bacterial cell wall…
Micro - Antibiotics MOAs
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Cell wall active agents
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glycopeptides bind to side chains (acyl-D-alanyl-D-alanine of NAM residues) - block elongation of peptidoglycan backbone (used for MRSA)
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Antimetabolites
sulphonamides, trimethoprim, dapsone
bacteria sysnthesise THF (tetrahydrofolate) using a no. of enzymes + incorporate it into DNA nucleotides (precursor)
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daptomycin
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spectrum
gram +ve, MSSA, MRSA, S epidermis, Strep (incl PRSP-pencillin resistant S pneumoniae), enterococcus faecium + faecalis (incl VRE)
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