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Brain Tumours (Signs (Focal Seizures (Parietal love: spreading tingling,…
Brain Tumours
Signs
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Focal Seizures
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Frontal lobe: limb jerking, head or eye deviation
Temporal lobe: deja vu, feeling of dread
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As tumour grows, brain is displaced downwards putting pressure on brainstem causing drowsiness, respiratory depression, bradycardia, coma and death
Treatment
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High Grade
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Prognosis: 6 months with no treatment, 18 months with treatment
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Symptoms
Focal neurological symptoms: weakness, sensory loss, ataxia
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Headache due to raised ICP: worse in morning, woken by headache, worse lying down, nausea
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Investigations
Brain biopsy: histology, molecular markers e.g. IDH mutation, chromosome 1p19q deletion, TP53 mutation
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High grade MRI: irregular mass, oedema, disruption of BBB
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Epidemiology
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Nearly 11,000 new cases a year in the UK
Incidence is 17 per 100,000
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Types
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Primary Malignant
Glioma: most common, tumour of astrocytes, oligodendrocytes, ependymal cells
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