viral hepatitis
Hep B
Hep C
Hep A
Hep E
VACCINE
RNA
Self-limiting
fecal-oral transmission
VACCINE
DNA
more serious
global health issue
technically a STI
hep B is also associated with hep B-associated delta virus
increases the pathology of hep B
NO VACCINE
RNA
most common globally
liked to transfer via blood transfusion
ie sharing needles
NO VACCINE
RNA
rare in Canada
similar to hep A but MUCH higher mortality rate
treatments
interferon
nucleoside analog antiviral
this is better tolerated than the interferon BUT increases the risk for resistance as this requires LONG TERM therapy
treatment
peg-interferon (makes the duration of the action much longer) PLUS ribavarin (nucleoside analog)
costly
flu-like adverse effects for most, also neurotoxicities common
by adding protease inhibitors (blocks the viral replication in the host cell) to the combo treatment you increase the efficacy of the other 2
better outcome than HBV