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Huntington's (Pathophysiology (Presents in middle age, There is…
Huntington's
Pathophysiology
Presents in middle age
There is atrophy and neuronal loss of striatum and cortex
Incurable, progressive, neurodegenerative disorder
Death within 15 years of diagnosis
Symptoms
Irritability
Depression
These symptoms are prodromal
Incoordination
Signs
Dementia
Fits
Chorea = abnormal involuntary jerky movements which are unpredictable
Aetiology
Expansion of CAG repeat on chromosome 4
Autosomal dominant
Treatment
There is no treatment to prevent progression
Counsel the patient and family