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Parkinson's (Signs (Resting tremor - often asymmetrical, Problems with…
Parkinson's
Signs
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Problems with fine movement: doing up buttons, small writing
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Non motor features: constipation, hallucinations, frequency, dribbling
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Treatment
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L-DOPA - dopamine precursor, start treatment late
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Cardinal Triad
Rigidity: due to increased tone, felt during rapid supination
Bradykinesia: slow initiation of movements, decreased blink rate, Parkinsonian gait (shuffling, decreased arm swing), inability to do fine movements e.g. doing up buttons
Tremor: at rest, unilateral, pill rolling of thumb over fingers
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Definition
Loss of dopaminergic neurones in the substantia nigra, associated with Lewy bodies in the basal ganglia, brain stem and cortex