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CR - Lung Tumours (i) (Presentation (Paraneoplastic syndrome (mediated…

- - - - cross-reacting Igs
      - production of physiologically active factors
      - interference with normal metabolic pathways
      - idiopathic
- - - - 95% epithelial
        
        non small cell carcinoma
        
        adenocarcinoma (most common, malignant glands)
        
        squamous cell carcinoma (2nd most common)
        
        large cell carcinoma
        
        not otherwise specified
        
        large cell neuroendocrine carcinoma
        
        carcinoid tumour
        
        neuroendocrine
        
        subdivisions based on mitotic activity
        
        typical
        
        grow slowly
        
        90%
        
        atypical
        
        rarer
        
        grow faster
        
        small cell carcinoma
        
        3rd most common
        
        neuroendocrine
        
        affect males > females, but female incidence is increasing
        
        cause more deaths than breast + prostate + colon combined
        
        aetiology
        
        smoking
        
        85% of cases were smokers
        
        carcinogen = 18 hydrocarbons
        
        urban dwelling (pollution)
        
        industrial exposures
        
        asbestos - mesothelioma, adenocarcinoma
        
        haematite (in iron ore)
        
        radon
        
        previous Hx of lung disease
        
        genetics (8-14%)
        
        aka bronchogenic/bronchial cancer
        
        often arises from major bronchi
      - non-epithelial
    - - can technically be from anywhere
      - multiple round deposits
      - colon
      - breast
      - renal cell carcinoma
      - prostate
      - melanoma
  - - - PET (cold as low turnover)
      - Bx (if v fatty = harmatoma)