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CR - COPD (i) (Intro (complications (incl significant extra-up effects)…

- - - - physiologically decreases once over 30 y/o by 30-60 ml/yr
      - reduction initially asymptomatic, symptoms once it's < 50%
- - - - leads increased no. of goblets cells + loss of ciliated epithelial cells
      - premalignant if dysplastic (squamous cell carcinoma)
- - - - air trapped in alveoli, gas exchange difficult
    - - with imperfect repair
      - lung neutrophils (normally sequestered) are stimed to increase in numbers + released elastase containing granules (elastolytic activity)