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Micro - Mycobacteria (i) (intro (Non TB mycobacteria = MOTT (mycobacteria…
Micro - Mycobacteria (i)
intro
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MTB complex
7 closely-related species, incl 3 human pathogens (TB, M bovis-from unpasteurised dairy products, M africanum)
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primary resp TB
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3 outcomes...
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invades bloodstream - haematogenous spread - disseminated (miliary TB) in liver, spleen, nodes, adrenal glands, bone, fallopian tubes
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Tb Tx
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non-conventional drugs, penetrate intracellularly
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1st line = rimfampicin (hep+discolouring body fluids), isoniazid (hep+peripheral neuropathy), pyrizinamide, ethambutol (optic neuritis)
for pul TB give all for 1st 2 months, then only rifampicin + isoniazid for remaining 4 months
2nd line = streptomycin, amikacin, kanamycin, P-aminosalicylic acid, capreomycin, ethanomide, moxifloxacin
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