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HORMONES AND REPRODUCTION DRUGS (MALE REPRODUCTIVE SYSTEM (ANDROGENS are…

- - - - SIDE EFFECTS
        Barbiturates, rifampin, tetracyclines, phenytoin: decreased serum estrogen levels.
        Corticosteroids: increased therapeutic and toxic effects of corticosteroids.
        Nicotine: Increased risk of thrombi and emboli
        Grapefruit juice: inhibition of metabolism of estradiols
        St. John’s wort: can affect metabolism of estrogens and can make estrogen-containing contraceptives less effective.
      - INDICATIONS
        Responsible for estrogen effects on the body.
        Affect the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH)Responsible for the proliferation of the endometrial lining.
      - MECHANISM OF ACTION
        Used for hormone replacement therapy (HRT) in small doses when ovarian activity is blocked or absent.
        Treat female hypogonadism and ovarian failure; to prevent postpartum breast engorgement..
      - ROUTE OF ADMINISTRATION Administered orally
      - CONTRAINDICATIONS Can interfere with the renal excretion of the drug and increase the risk for potential adverse effects on fluid and electrolyte balance
      - NAMES
        ESTRADIOL, ESTROGENS CONJUGATED,ESTROPITATE,DESOGESTREL,ETONOGESTREL,LEVONORGESTREL,ESTROGENS ESTERIFIED
    - - SIDE EFFECTS
        Barbiturates, carbamazepine, phenytoin, griseofulvin, penicillin, tetracyclines, rifampin: reduced effectiveness of progestins.
        St. John’s wort: can affect the metabolism of progestins and can make progestin-containing contraceptives less effective.
      - ROUTE OF ADMINISTRATION
        Administered oraly and its onset varies with each drug.
      - MECHANISM OF ACTION
        Inhibit the secretion of FSH and LH.
        Prevent follicle maturation and ovulation as well as uterine contraction.
      - INDICATIONS
        To inhibit the development and maturation of follicles.
        Stimulates the hypoyhalamus to prevent the release of gonadotrophin
      - CONTRAINDICATIONS
        Progestins have effects on the vasculature of the uterus
        Drosperinone is contraindicated in patients who are at risk for hyperkalemia due to its antimineralocorticoid effects and the risk of hyperkalemia.
        Gives rise to conditions such as epilepsy and cardiac conditions.
      - NAMES
        NORGESTREL,PROGESTERONE,ULIPRISTAL,MEDROXYPROGESTERONE,NORETHINDRONE ACETATE