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CHOLINERGIC DRUGS (ATROPINE (INDICATIONS (Prevention of nausea, vomiting,…
CHOLINERGIC DRUGS
ATROPINE
MECHANISM OF ACTION
It is used to depress salivation and bronchial secretions and to dilate the bronchi,
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It works by blocking only the muscarinic effectors in the parasympathetic nervous system and the few cholinergic receptors in the SNS.
INDICATIONS
Prevention of nausea, vomiting, and dizziness associated with motion sickness.
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CONTRAINDICATIONS
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Intestinal atony, paralytic ileus, GI obstruction. Can be exacerbated with further slowing of GI activity.
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SIDE EFFECTS
CNS: blurred vision, pupil dilation, photophobia, cycloplegia, increased intraocular pressure, weakness, dizziness, insomnia
CV: tachycardia, palpitation
GI: dry mouth, altered taste perception, nausea, heartburn, constipation
GU: urinary hesitancy and retention, heat prostration
NURSING CONSIDERATIONS
NURSING ASSESSMENT
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Assess neurological status (e.g., orientation, affect, reflexes) to evaluate any CNS effects.
Assess abdomen (e.g., bowel sounds, bowel and bladder patterns, urinary output) to evaluate for GI and GU adverse effects.
Monitor laboratory test results to determine need for possible dose adjustments and to identify potential toxicity.
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IMPLEMENTATION
Ensure proper administration of the drug to ensure effective use and decrease the risk of adverse effects.
Monitor patient response (e.g., blood pressure, ECG, urine output) for changes that may indicate need to adjust dose.
Provide comfort measures (e.g., sugarless lozenges, lighting control, small and frequent meals) to help patient cope with drug effects.
Provide patient education about drug effects and warning signs to report to enhance knowledge about drug therapy and promote compliance
EVALUATION
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Monitor for adverse effects (e.g., photophobia, heat intolerance, urinary retention).
Evaluate patient understanding on drug therapy by asking patient to name the drug, its indication, and adverse effects to watch for.
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BETHANECHOL
MECHANISM OF ACTION
Direct-acting cholinergic agonists occupy receptor sites for ACh on the membranes of the effector cells causing increased stimulation.
Effects include
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bronchoconstriction and increased bronchial mucus secretion,
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INDICATIONS
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and is used to treat non-obstructive postoperative and postpartum urinary retention to treat neurogenic bladder atony.
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CONTRAINDICATIONS
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Bradycardia, hypotension, vasomotor instability, and coronary artery disease.
Peptic ulcer, intestinal obstruction, or recent GI surgery.
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SIDE EFFECTS
CV: bradycardia, heart block, hypotension, cardiac arrest
GI: nausea, vomiting, cramps, diarrhea, increased salivation
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Others: flushing, increased sweating
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NURSING CONSIDERATIONS
ASSESSMENT
Assess for contraindications or cautions (e.g. history of allergy to drug, GI obstruction, pregnancy or lactation status, etc.) to avoid adverse effects.
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Assess orientation, affect, reflexes to monitor CNS drug effects.
Assess vital signs, especially pulse and blood pressure to monitor for possible excess stimulation of the cardiac system.
Assess abdomen, auscultating for bowel sounds and palpating for distention.
Monitor intake and output, noting any complaints of urinary urgency to monitor for drug effects on the urinary system.
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IMPLEMENTATION
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If drug is given intravenously, administer slowly to avoid severe cholinergic effects.
Monitor patient response closely (e.g., blood pressure, ECG, urine output)
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Discontinue drug if excessive salivation, diarrhea, emesis
Provide safety precautions if the patient reports poor visual acuity in dim light to prevent injury.
Provide comfort measures (e.g., quiet room, support and relaxation measures)
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EVALUATION
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Monitor for adverse effects (e.g. GI upset, CNS changes, CV changes).
Evaluate patient understanding on drug therapy by asking patient to name the drug, its indication, and adverse effects to watch for.
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CARBACHOL
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Therefore the route,storage,nursing considerations,contraindications,mechanism of action,indications and side effects is the same