injury to basal epith--> Within ws manifests as erythema, edema, and alopecia.
skin & subcut undergo repair--> permanent hyperpigmentation clinically apparent; Histologically, epidermis appears thickened, but functional integrity compromised
Severe radiation injury--> complete loss of epidermis w/ persistent edema & fibrinous exudate
Re-epith from unaffected wound edges & from recuperating dermal adnexa begins within 10 to 14 days of exposure, provided other parameters are optimized (nutrition, infection, etc.). Chronic changes result from thrombosis and necrosis of capillaries, presenting months to years after the inciting event, ultimately leading to fibrosis and possible ulcers. Chronic skin changes include thinning, hypovascularization, telangiectasia of remaining vessels, ulceration, fibrosis with loss of elasticity, and increased susceptibility to trauma and infection. Chronic radiation skin injury includes delayed ulcers, fibrosis, and telangiectasias that present weeks to years after exposure