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Nephrotic Syndrome (Pathophysiology (Membranous nephropathy: immune…
Nephrotic Syndrome
Pathophysiology
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The filtration barrier of the kidney is formed by podocytes, the glomerular basement membrane and endothelial cells
Podocytes wrap around glomerular capillaries and maintain the filtration barrier. They prevent large molecular weight proteins from entering the urine
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Minimal Change Disease
In adults, can be idiopathic, paraneoplastic or associated with drugs
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Membranous Nephropathy
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Caused by malignancy, hep B, drugs, autoimmune, idiopathic
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Mesangiocapillary GN
Biopsy: mesangial and endocapillary proliferation, thickened capillary basement membrane, Ig or complement staining
Treat underlying cause, give ACE inhibitors and immunosuppress
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Immune Complex Mediated
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Underlying causes: SLE, hep C
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Triad of proteinurina, hypoalbuminaemia and oedema