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Ventilation (Ventilation (Minute ventilation = TV x RR, Alveolar = TV -…
Ventilation
Ventilation
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Compliance: Lung and chest wall, Change in pressure required to change volume.
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Diffusion
Perfusion
Max at lung base, upright
Low ventilation, normal perfusion = Deoxygenated blood
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Normal ventilation, low perfusion= ^ dead space (wasted)
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Investigation: TLCO/DLCO (diffusing capacity): Transfer factor. Breath in CO during breath hold, measure uptake. Reflects absorption ∝ thickness of alveolar membrane.
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Fick's Law: Rate of gas transfer through sheet of tissue ∝ Tissue area and difference in gasPa between the sides, and is I∝ tissue thickness.
CO2 diffuses 20x faster than O2.
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