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Regenerative Medicine Assignment (Key points how to make hepatocytes (what…
Regenerative Medicine Assignment
Introduction
Background
hybrid solutions
Objectives of paper
Outline structure
Conclusion
Short term solution
Long Term solution
How long will it take?
How do we know liver function is working
diagnose state of health following transpantation
Approaches
Decelluarisation
Description
where does organs come from
other humans
Other species
Advantages
Disadvantage
3d printing
Limiting factors for all approaches
Requirements
cell culture
how do we know cells are hepatocytes
Key points how to make hepatocytes
what enzymes might they scerete
Soak identify stain HNF4 (Hepattocyte Nuclear Factor)
markers
capable of communicating
bile channel - junctional proteins
Transporter proteins
look for enzymes that metabolise bilirubin
Alginates
it doesnt break down using aliginase
how do you stabilise the scafflod
can you make collagen more biologically stable
sources of cells :
whats is needed?
scaffold
bioreactor