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Vasculitis (Types (Large: giant cell arteritis, Takayasu's arteritis,…
Vasculitis
Types
Large: giant cell arteritis, Takayasu's arteritis
Medium: polyartertitis nodosa, Kawasaki disease
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Small: ANCA +ve vasculitis or ANCA -ve. ANCA = anti-neutrophil cytoplasmic antibodies. They are specific antibodies for antigens in cytoplasmic granules of neutrophils and monocyte lysosomes
Polyarteritis Nodosa
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Symptoms
Renal: Hypertension, haematuria, proteinuria, renal failure
Cardiac: angina, heart failure, pericarditis
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GI: Pain, perforation, malabsorption
Systemic: fever, malaise, weight loss, myalgia
GU: Orchitis, tenderness, pain
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Features
Causes aneurysms and thrombosis in medium sized arteries, leading to infarction of those organs
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Giant Cell Arteritis
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Symptoms
Cranial: headache, temporal artery + scalp tenderness, tongue/jaw claudication, sudden unilateral blindness
Extra-cranial: malaise, dyspnoea, weight loss, morning stiffness, weak pulses
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Microscopic Polyangiitis
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Treatment
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If untreated, mortality is 90% within 2 years
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Features
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Necrotizing granulomatous vasculitis of arterioles, capillaries and post capillary venules
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Takayasu's Arteritis
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Features
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Granulomatous inflammation causes stenosis, thrombosis + aneurysms
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Pathophysiology
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Histology
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Vessel wall infiltration by neutrophils, mononuclear cells + giant cells
Definition
Inflammatory disorder of blood vessel walls, leading to subsequent impaired blood flow