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Topical drugs (Mechanism of Action (Benzoyl peroxide exhibits…
Topical drugs
Mechanism of Action
Benzoyl peroxide exhibits antimicrobial effects against Propionibacterium acnes, which is the predominant organism in sebaceous follicles and comedones.
The antibacterial effects of benzoyl peroxide are due to the release of free-radical oxygen species, which are capable of oxidizing bacterial proteins.
Benzoyl peroxide also demonstrates keratolytic activity, which produces drying and desquamative actions that contribute to its efficacy in comedone treatment.
Resolution of acne usually occurs within 4—6 weeks of initiation of treatment. Resolution coincides with a reduction in levels of P. acnes, lipids, and free fatty acids in the skin follicle.
Nursing concideration
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Storage conditios
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
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Contraindications
Use of benzoyl peroxide products in patients with skin disease such as dermatitis, seborrhea, and eczema or with skin abrasion or inflammation,
Patients should limit their sunlight (UV) exposure and use sunscreen while using benzoyl peroxide products to decrease the risk for skin irritation.
Children- The safety and efficacy of benzoyl peroxide products have not been established in children.
Pregnancy
Benzoyl peroxide products are considered FDA pregnancy risk category C agents. It is not known if benzoyl peroxide causes fetal harm or can affect reproductive capacity.
Route of Adminstration
Do not use near the eyes, nose, mouth, or other mucous membranes. Do not apply to areas of raw or irritated skin.
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Instruct patients not to apply other topical products to the same area within 1 hour of applying benzoyl peroxide, unless indicated by the prescriber.
Cream or lotion: Before applying benzoyl peroxide, wash affected area with a non-medicated cleanser and pat dry. Apply enough medication to cover the area and rub in gently.
Indication
Apply topically to affected area once daily. May gradually increase the number of applications to 4 times per day, as needed.
Initiate therapy with 2.5—5% formulations and gradually increase strength to 10% after 3—4 weeks, if needed, or sooner if tolerance to the lower strengths is noted
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Continued use may be required to maintain the desired therapeutic response. Patients with fair skin or patients in arid environments should initiate therapy at once daily intervals and then gradually increase applications as tolerated.
Name
benzoyl peroxide
is a medication and industrial chemical. As a medication, it is used to treat mild to moderate acne. For more severe cases, it may be used with other treatments.