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Acute Pancreatitis (Aetiology (Autoimmune, Scorpion venom, Steroids,…
Acute Pancreatitis
Aetiology
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Hyperlipidaemia, hypothermia, hypercalcaemia
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Ethanol (alcohol, 35% of cases)
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Also - pregnancy, neoplasia and idiopathic causes
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Pathophysiology
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The local inflammatory response an lead to systemic inflammation, causing multiple organ failure
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Oedema and fluid shifts, causing hypovolaemia as extracellular fluid is trapped in the gut, peritoneum and retroperitoneum
Signs
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Cullen's sign = periumbilical bruising from blood vessel autodigestion and retroperitoneal haemorrhage
Treatment
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Glasgow Criteria
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Three or more positive factors detected within 48 hours suggest severe pancreatitis and prompt transfer to ITU
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