Please enable JavaScript.
Coggle requires JavaScript to display documents.
Antineoplastic agents (Alkylating agents (Nursing considerations (Side…
Antineoplastic agents
Alkylating agents
-
Mechanism of action
Forms DNA-DNA intrastand cross-links between DNA bases guanine and adenine and between guanine and guanine. DNA cross-links cannot be repaired by cellular machine so cell undergoes apopotosis
-
-
Antimetabolites
-
-
Mechanism of action
Inhibits the synthesis of DNA, RNA, Trymidylates and proteins
-
Taxane
-
-
Mechanism of action
Blocks progression of mitosis and prolonged activation of the mitotic check point triggers apoptosis
Nursing considerations
Side effects
SOB, severe fatigue and skin rash
-
Change in taste, Joint pains and dysphagea
Nausea, vomiting and loss of appetite
-
Storage
20-30 degrees celcius, away from sunlight
-
-
-
Enzymes
-
-
mechanism of action
catalyses the conversion of L-asparigine to acid and ammonia, this deprives the leukemia cell of circulating asparagine which lead to cell death
-
-
DNA topoisomarase
-
-
Mechanism of action
Interlaces between DNA bases. This intercalates disrupts the DNA replication and ultimately leads to break in DNA strand
-
-