Please enable JavaScript.

Coggle requires JavaScript to display documents.

Micro - Chlamydia (Life cycle (0 hrs: elementary body enters host cell, 12…

- - - - myocarditis
      - Guillain-Barre syndrome (paralysis)
      - meningoencephalitis
      - reactive arthritis
  - - - atypical pneumonia + systemic symptoms (acute ILI, esp fever)
    - - endocarditis
      - hep
      - encephalitis
      - resp failure
    - - can't culture on agar - obligate intracellular pathogen
      - NAAT/PCR on resp specimen
      - serology: look for 4-fold increase in IgG titre over 2 wks
    - - NO PEPTIDOGLYCAN IN CELL WALL - CAN'T USE CELL WALL SYNTHESIS INHIBITORS
      - tetracycline (doxycycline - not for kids as causes tooth staining + enamel hypoplasia) or macrolide (azithromycin)
  - - - caused by serotypes A-C
      - problem in developing countries
      - leading infectious cause of blindness
      - trichiasis (ingrowing eyelashes) -> cicatricial disease (corneal scarring + opacification) -> blindness
      - keratoconjunctivitis (inflamm of cornea + conjunctiva)
      - contact spread
        
        direct human-human via secretions
        
        indirect via handkerchiefs/towels/flies
      - clinical Dx, no lab tests needed
      - Tx = SAFE
        
        surgical correction of trichiasis
        
        antibiotics (doxycycline or azithromycin)
        
        Facial cleanliness
        
        environmental improvements
    - - caused by serotypes D-K
      - vertical transmission (contracted in birth canal )
      - inflamm + discharge from eyelids @ 5-14 days old, possibly atypical pneumonia too
      - Dx: conjunctival scraping (NAAT/antigen detection)
      - Tx baby, mum (better to tx before she gave birth to prevent transmission) + mum's partners
      - large follicles most predominant in lower palpebral fornix
    - - cervicitis in females
        
        often asymptomatic/non-specific symptoms (discharge, intermenstrual/post-coital bleeding)
        
        25% progress to urethritis (often misdiagnosed as UTI due to similar symptoms, e.g. dysuria, polyuria)
        
        can progress to PID
        
        pain, infertility
        
        cause Fitz-hugh-curtis syndrome (perihepatitis)
        
        can cause pregnancy complications - premature rupture of membranes (PROM), preterm delivery, vertical transmission
      - in males
        
        urethritis
        
        50% symptomatic
        
        discharge, dysuria
        
        acute epididymitis
        
        unilateral testicular pain
        
        tenderness, hydrocele, palpable swelling
        
        proctitis
        
        inflamed rectal tissue
      - Dx
        
        NAAT
        
        vulvo-vaginal swabs, endocervical swabs, first-catch urine, urethral swabs, rectal swabs
        
        test for other STIs (gonorrhoea, HIV, syphilis)
      - Tx
        
        doxycycline + azithromycin
        
        contact tracing NB
      - Lymphogranuloma Venereum (LGV)
        
        serotype L1-3
        
        common in tropics
        
        genital ulcer followed by regional lymphadenopathy (buboes)
        
        Dx
        
        aspirate buboes
        
        NAAT + serology
        
        test for other STIs
        
        Tx
        
        3 wk doxycycline
        
        contact tracing