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Research Proposal (UAA + ADC (Could invoke undesired immunological…
Research Proposal
UAA + ADC
Could invoke undesired immunological response
Difficult/ special tech and agents are required
:red_cross: Aller-salvia, B. et al, 2018 Angewandte
Antibody's with positron emission tomography
Combine with David Perrin's work
Check out Skovsgaard, M. B. et al, 2019, Bioconjugate Chemistry, DOI: 10.1021/acs.bioconjchem.9b00013
Theragnostics
What makes a good theragnostic?
Targetted
Fluorogenic
Fluorescence DIES as cancer dies
Usually MRI/ PET/SPECT or NIR FLuorescence
Most people use QDs :red_cross:
Fluorescent nucleotides for aptamers
Fluorgenic
Environment based (ICT?)
fragments of an enzyme
find minimal fragment of CrabPII
Transplant diagnostics
MRI probes
Fluorescence probes?
Studying Signalling pathways