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CYCLOSPORIN (side affects (diarrhoea, GI discomfort, decreased liver…
CYCLOSPORIN
side affects
diarrhoea
GI discomfort
decreased liver function
altered taste
(rare) reversible pneumonitis
indications
prevention of graft versus host disease
used in the following if other therapies have been ineffective
induction of remission in nephrotic syndrome
severe active rheumatoid arthritis
severe psoriasis
mechanism of action
potent immunosuppressive agent
blocks lymphocytes and antigen-triggered lymphokine released by activated T-cells
route of administration
orally
intravenously
storage conditions
(room temperature (24°C−26°C)
contraindications
enhances myelosuppressive effects if given with
bone marrow depressing agents