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HORMONES AND REPRODUCTIVE DRUGS (Hormone replacement thraphy (Nursing…
HORMONES AND REPRODUCTIVE DRUGS
Hormone replacement thraphy
Raloxifene
Mechanism of action
Selective estrogen receptor modulator that affects some receptors like estrogen,
indications
prevents Osteoporosis
Invasive breast cancer prophylaxis in postmenopausal women
Nursing considerations
Contraindications :
History of Thromboembolic events
Women at risk for stroke
Women who may become pregnant
Effect
Flu-like symptoms
Sinusitis
arthralgia
Storage Conditions
at room temperature
route of administration
Taken orally
Female Sex Hormones
Estrogens
Mechanism of action
steroid hormone that play a pivotal role in the regulation of mammalian reproduction.
estrogen regulate the development and function of the uterus.
This hormone act by regulating the transcription of specific genes in the uterus.
this hormone is mediated by their specific hormone receptors. These receptors are nuclear transcription factors, whose transcriptional regulatory activity is mediated by the binding of the specific steroid .
receptors bind hormone, they can bind to specific cis-acting sequences in the promoter region of responsive genes and regulate transcription of these gene
Nursing considerations
Contraindications
Hepatic dysfunction
Allergy to estrogens
Lactating women
Efffects
uid retention, electrolyte disturbances, headache, dizziness,
nausea, vomiting, abdominal cramp, bloating, colitis,
Storage Conditions
Store at room temperature below 30 degrees C away from light and moisture.
Keep all medicines away from children and pets.
route of administration
orally
transdermal
subcutaneous
indications
ormone replacement therapy (HRT
Treat female hypogonadism
o slow bone loss in osteoporosis
Male sex hormones
Testosterone,Duratest, Testoderm
Mechanism of action
PRIMARY androgen that promotes growth and development of male sex organs
indications
endometriosis, fibrocystic breast disease
Growth and development of male sex organs
gonadotropin-releasing hormones (GnRH)
Nursing considerations
Contraindications
Allergy to androgens
Liver dysfunction, CV disease.
Effect
acne, edema, hirsutism
flushing, sweating, vaginitis, nervousne
oice, oily skin and hair, weight gain
Storage Conditions
keept refrigareted,
route of administration
Transdermal,