Please enable JavaScript.
Coggle requires JavaScript to display documents.
floxuride (mechanism of action (rapidly catabolized to 5-Fluorouaracil,…
floxuride
mechanism of action
rapidly catabolized to 5-Fluorouaracil
which is the active form of drug
primary effect is interference with DNA synthesis
and to lesser extent
inhibition of KNA formation through
drugs incorporate into RNA
thus leading to the production of
fraudulent RNA
side effects
diarrhea
lip and mouth sores
stomach pain
black, tarry stool
heartburn
indications
metastatic GI adenocarcinoma
stomach cancer
palliative management
contraindications
poor nutrition state
depressed bone marrow function
storage condition
reconstituted vials should be stored under refrigeration 2 degrees to 8 degrees celsius
discard after 14 days
route of administration
intra arterial infusion