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hormonal and reproductive drugs (Medroxyprogesterone (Contraindications…
hormonal and reproductive drugs
Medroxyprogesterone
Indications
amenorrhea
Abnormal uterine bleeding due to hormonal imbalance without organic pathology.
To prevent endometrial hyper plasia in postmenopausal women
Mechanism of action
Inhibition of follicular development and the absence of a LH surge prevent ovulation
Secondary mechanism of action of all progesterone containing contraceptive is inhibition of sperm penetration by changes in the cervical mucus.
Contraindications
High blood pressure
Diabetes.
Family history of breast cancer.
Porphyria.
Side effects
Nausea
Headache
Bloating
route of administration
By oral and intramascular.
Storage condition
In a place of 20 degrees celcius.
Oxymetholone
Mechanism of action
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors
Indications
Anemia
Myelofibrosis
Hypoplastic anemias
contraindications
Breast cancer
Prostate cancer
Side effects
breast swelling or tenderness.
Feeling restless or excited.
Male pattern baldness.
route of administration
Oral administration.
Estradiol
Mechanism of action
It act on receptors present inside the cell, that can activate or deactivate transcription in the nucleus.It interact with the target cell receptor within the cytoplasm of the cell.
Indications
Teat severe symptoms of vulvar and vaginal atrophy associated with the menopause.
Treat the hypoestrogenism due to hypogonadism, castration or primary ovarian failure.
Treat severe vasomotor symptoms associated with the menopause.
contraindications
History of deep vein thrombosis.
Undiagnosed abnormal genital bleeding.
History of pulmonary embolism
Side effects
Breast enlargement.
Changes in menstrual periods.
Abdominal cramping.
route of administration
Oral, buccal, sublingual, intranasal, transdermal, vaginal, and intramuscular.
Storage condition
Liquid must be stored in 20 degrees celcius area.
Mestranol
Mechanism of action.
It is used as the estrogen component of many combination oral contraceptive. Is as an estrogen receptor agonist.
Indications
Oral contraceptive.
Contraindications
Breast cancer.
Uterine cancer
Pregnancy
Side effect.
Cerebral hemorrhage
Depression
Thrombosis
Route of administration
Oral administration.