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CHAPTER 2 (i) (ADVANTAGES
OF CDDS (Decreased dosing freq, Reduced rate of…
CHAPTER 2 (i)
ADVANTAGES
OF CDDS
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Better drug utilization, enhanced bioavailability
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ADDS
Involve scientific site-targeting within the body, or it might involve facilitating systemic pharmacokinetics.
ADDS improves drug potency, control drug release to give sustained therapeutic effect, provide greater safety.
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IDEAL DDS:
FEATURES
Biocompatible, comfortable for the patient, increase the bioavailability of the drug.
Transport the drug intake to the side of action, safe from accidental release.
Easy to manufacture and sterilize, simple to administer and remove.
TYPES OF
CDDS
Delayed release tablet as enteric coated to delay release of the medication until the tablet has passed through the stomach to prevent the drug from being destroyed or inactivated by gastric juices or where it may irritate the gastric mucosa.
- Aspirin irritates the gastric mucosal cells of the stomach. An enteric coating on the tablet prevents the tablet from dissolving and releasing its contents at the low pH in the stomach. The coating and tablet later will dissolve and release the drug in the higher pH of duodenum.
- Mesalamine is delayed release tablet coated with an acrylic-based resin that delays the release of mesalamine until it reaches the terminal ileum and colon.
Designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration.
It is type of solid dosage form that dissolves or disintegrate in the oral cavity without the help of water or chewing.
Fast dissolution is achieved by forming loose network or by effervescent agent (form bubble) or with mixture of disintegrating agent and swelling agent.
Hygroscopic, able to absorb moisture from air. So, special packaging needed.
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Basic goal is to achieve steady state blood level that is therapeutically effective and non toxic for an extended period of time.
Designed to achieve prolonged therapeutic effect by continuously releasing active ingredient over an extended period of time after administration of single dose.
CONVENTIONAL
DOSAGE FORM
Designed to give rapid and complete release of the drug contained there in immediately after administration
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WHY CDD?
Simple, fast-acting responses (conventional forms)
via oral or injection delivery routes
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- Fast Dissolve Drug
Delivery System (Flash)