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azacitidine (side effects (pyrexia, diarrhea, fatigue, anemia, lcough,…
azacitidine
side effects
pyrexia
diarrhea
fatigue
anemia
lcough
nausea
dyspnea
weakness
storage conditions
store your medication seperately from others
store your prescription in a safe, cool, dry place
out of sight and reach of children
keep medication in good lighting
store in room temperature away from light
store at 77 degress F
discard unused portion
mechanism of action
thought to induce antineoplastic activity via two mechanisms
inhibition of DNA methyltransferase at low doses
causing hypomethylation of DNA
direct cytotoxicity in abnormal hematopoietic cells in the bone marrow
through its incorporation into DNA and RNA at high doses
resulting in cell death
contraindications
liver cancer
pregnancy
liver and kidney dysfunction
decreased neutrophils
decreased blood platelets
breast feeding
route of administration
iv administration
subcutaneous
iv preparations
iv incompatibilities