otic drugs
generic name
acetic acid / aluminum acetate
generic name
generic name
ciprofloxacin
ofloxacin
mechanism of action
Ciprofloxacin is a broad-spectrum antibiotic of the fluoroquinolone class. It is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, and a type II topoisomerase, topoisomerase IV, necessary to separate bacterial DNA, thereby inhibiting cell division.
indications
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• Lower Respiratory tract infections due to Gram-negative bacteria
- pneumonia
- exacerbations of chronic obstructive pulmonary disease
- broncho-pulmonary infections in cystic fibrosis or in bronchiectasis
• Chronic suppurative otitis media
• Acute exacerbation of chronic sinusitis especially if these are caused by Gram-negative bacteria
• Urinary tract infections
• Genital tract infections
- gonococcal uretritis and cervicitis due to susceptible Neisseria gonorrhoeae
- epididymo-orchitis including cases due to susceptible Neisseria gonorrhoeae
- pelvic inflammatory disease including cases due to susceptible Neisseria gonorrhoeae
• Infections of the gastro-intestinal tract (e.g. travellers' diarrhoea)
• Intra-abdominal infections
• Infections of the skin and soft tissue caused by Gram-negative bacteria
• Malignant external otitis
• Infections of the bones and joints
contra-indications
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Clostridium difficile infection
Diabetes
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
low amount of magnesium in the blood
low amount of potassium in the blood
Lower Seizure Threshold
pseudotumor cerebri
peripheral neuropathy
Myasthenia Gravis
Very Rapid Heartbeat - Torsades de Pointes
Slow Heartbeat
prolonged QT interval on EKG
Abnormal EKG with QT changes from Birth
Kidney Transplant
Inflammation of the Tendon
Rupture of a Tendon
side effects
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diarrhea
dizziness
drowsiness
headache
stomach upset
abdominal pain
nausea/vomiting
blurred vision
nervousness
anxiety
storage conditions
Store in tight, light-resistant container as defined in the USP-NF.
This material should be handled and stored per label instructions to ensure product integrity.
Ciprofloxacin injection USP: Store in a cool place between 8 and 15 deg C
Protect from light and freezing.
Ciprofloxacin for oral suspension: Prior to reconstitution, store below 25 deg C (77 deg F)
Ciprofloxacin tablets USP: Store below 30 deg C (86 deg F) in a well closed container.
route of administration
oral administration
intravenous route
intratympanically route
intraperitoinial route
local route
mechanism of action
Aluminum Acetate is an astringent.
An astrignent is a chemical that tends to shrink or constrict body tissues,
The shrinkage or constriction is through osmotic flow of water
Astringent medicines cause shrinkage of mucous membranes
often used internally to check discharge of mucous secretions
indications
This medication is used to treat an outer ear infection (external otitis).
This medication also causes drying of the ear canal, helping to cure the infection.
Contra-indications
Hole in the Ear Drum
side effects
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest.
.
Very bad ear irritation
Storage conditions
Store at room temperature away from light and moisture.
Do not store in the bathroom.
Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
Roate of administartion
local route
mechanism of action
It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV,[56] which is an enzyme necessary to separate (mostly in prokaryotes, in bacteria in particular) replicated DNA, thereby inhibiting bacterial cell division.
Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria
indications
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Acute bacterial exacerbations of chronic bronchitis
Community-acquired pneumonia
Uncomplicated skin and skin structure infections
Nongonococcal urethritis and cervicitis
Epididymitis
Mixed Infections of the urethra and cervix
Acute pelvic inflammatory disease
Uncomplicated cystitis
Complicated urinary tract infections
Prostatitis
Acute, uncomplicated urethral and cervical gonorrhea.
cotraindications
nursing mothers
patients with psychiatric illness
during pregnancy
epilepsy
liver diseases
side effects
nausea
vommiting
diarrhea
headache
insomnia
storage conditions
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
any discarded medicine must be kept out of the reach of children.
Keep out of the reach of children.
.Do not keep outdated medicine or medicine no longer needed.
Keep the medicine from freezing and do not refrigerate.
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Antipyrine octic solution
Antipyrine is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.
Indication
Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes..
Side effects
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glycerin that helps to soften earwax, congestion, and swelling
used to relieve pain
help remove earwax (cerumen)
burning/stinging/redness/new pain in or around the ears.
Hypersensitivity
bluish skin
severe tiredness or weakness.
Contra-indications
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Porphyria
systemic mastocytosis
bacterial infection of middle ear
Hole in the Ear Drum
Storage and conditions
Store at room temperature 1525ºC (5977ºF), to maintain product
integrity.
Protect from heat and light.
Protect from freezing.
Use before date marked on carton and/or container.
When using this product: do not touch tip of container to any surface to avoid
contamination
Route of administration
local route