Please enable JavaScript.
Coggle requires JavaScript to display documents.
INTRODUCTION TO DRUG DELIVERY SYSTEM (FACTORS INFLUENCE DRUG ROUTE…
INTRODUCTION TO DRUG DELIVERY SYSTEM
Drugs
Substances intended for use in the diagnosis, cure, treatment, or prevention of disease in human or animals.
Substances that bring changes in biologic function through its chemical actions.
May be synthesized within the body. E.g: Insulin, estrogen.
May be derived from natural products or chemicals
COSMETIC: Product intended to be rubbed, poured, sprinkled or sprayed on, introduced into, or otherwise applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance.
PRODUCT CAN BE
A COSMETIC AND
A DRUG:
Antidandruff shampoo
Cleanses hair, treats dandruff.
Moisturizer with SPF
Beautifies skin, prevents cancer.
PRODUCT SAFETY
ADVERSE DRUG REACTION
A response to a drug which is noxious and unintended and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease or for modification of physiological function.
Patient injury caused by a medicine taken in therapeutic doses.
E.g: ANAPHYLAXIS
An acute allergic reaction to an antigen (foreign compound) to which body has become hypersensitive
TYPES OF ADR
TYPE A
Exaggerated pharmacological response
Not suitable for asthma patient
TYPE B
Non-pharmacological
Allergic reactions (e.g, penicillin, anaphylaxis)
TYPE C
Continuous or long term
Osteoporosis with oral steroids
TYPE D
Delayed (lag time)
Tetratogenic effects with anticonvulsants
TYPE E
Withdrawal syndrome (addiction) with benzodiazepines
TYPE F
Failure of efficacy (no response)
Resistance to antimicrobial
ADR MANAGEMENT
STEP 1. Evaluate the nature of the event
Obtain detailed history of the patient
Classify severity of the reaction
i. Severe (fatal or life threatening)
ii. Moderate (hospitalization)
iii. Mild (symptoms require discontinuation of therapy)
iv. Incidental (mild, patient can choose to continue or not)
STEP 2. Establish the cause
Use the Naranjo algorithm to assess the patient's reaction
Evaluate the quality of the medicine
STEP 3. Take corrective and follow-up action
Will depend on cause and severity
Educate and monitor prescribers
Notify drug regulatory authorities and manufacturers
Educate and warn patients
DRUG DELIVERY
The method or process of administrating
pharmaceutical compound to achieve a
therapeutic effect in humans or animals
Enternal
Oral
Sublingual
Rectal/Suppository
Parenteral
Intravenous
Intramuscular
Subcutaneous
Intradermal
Intraosseous
Topical
Skin
Oral inhalation
Nasal inhalation
ENTERNAL
ORAL
Safest, most common, convenient, economical
Non invasive and painless
Don't need to be sterile so drugs is cheaper
Limitation:
i. Slow action, not suitable for emergency
ii. May causes nausea and vomiting
iii. Had to go through First Pass Metabolism
iv. Absorption of drug is varied
Dosage forms:
Capsules, powders, tablets, syrup,
emulsion, suspension
SUBLINGUAL
Place under tongue or buccal allows drug to diffuse into network and enter the systemic circulation directly under tongue or crushed in mouth and spread over the buccal mucosa
Absorption is relatively rapid action can be produce in a minutes
Limitation: Inconvenient, one can spit the drug once the desired action of drug obtained
Advantages: Liver and gut are by passed. Drugs are protected from first pass metabolism and drugs are directly into the systemic circulation. (E.g, Lorazepam, treat anxiety)
Dosage forms:
Tablets, lozenges, gum.
RECTAL / SUPPOSITORY
Certain irritating and unpleasant drug for their systemic effect
In this form, drug is mixed with a waxy substances that dissolves or liquefies after it is inserted into the rectum
Absorption is slower, irregular and unpredictable
Rectal inflammation can occur
E.g. Diazepam, paraldehyde, ergotamine
PARENTERAL
Introduce drugs directly across the body's barrier defense into the systemic circulation
Drugs that are poorly absorbed from the GIT (heparin) and agents that are unstable in GIT (insulin)
For unconscious patients and circumstances where rapid onset of action needed
Limitation: Irreversible, cause pain, fear, local tissue damage, infections.
Advantage: Highest bioavailability and not subject to first pass metabolism
Major: IV, IM, SC
IV
Placing drug directly into bloodstream
Advantage:
Precise, accurate, immediate onset of action, 100% bioavailability
Disadvantage:
i. Risk of embolism, a blockage causing piece of material, inside of blood vessel.
ii. High concentration attained rapidly leading to greater risk of adverse effects
IM
Into skeletal muscle
The best site is deltoid muscke in the shoulder or the gluteus muscle in the buttocks
Advantage:
Suitable for injection of drug in aqueous solution (rapid action) and drug in suspension or emulsion (sustained release)
Disadvantage:
Pain at injection sites for certain drugs
TOPICAL
Produce local effect to:
Skin (percutaneous):
E.g. Allergy testing, topical local anesthesia.
Mucous membrane of respiratory tract (oral inhalation):
E.g. Asthma / Nebulizer
Nasal inhalation:
E.g. Decongestant nasal spray
Ear drops. Applying drug into ear canal:
E.g. Otitis externa
Eye drops. Ocular administration is the application of a drug to the eye. Conjunctival mucosa or lining of the inside of the eyelid
E.g. Conjunctivitis
Topical Dose Forms
Skin
i. Creams
ii. Ointments
iii. Lotions
iv. Gels
Nasal
i. Sprays
ii. Aerosol (pressure)
iii. Drops (instillation)
Eye or Ear
i. Solutions
ii. Suspensions
iii. Ointments
FACTORS INFLUENCE DRUG ROUTE
Physical and chemical properties of drugs
Rate and extent of drug absorption
Rapidity at which response is desired
Accuracy of dose required
Condition of patients
Effect of digestive juice and
first pass metabolism of drugs
Site of desire action
BENEFITS OF ADDS
Optimum dose at right time and right location
Efficient use of expensive drugs,
excipients and reduction in production cost
Beneficial to patients, better therapy,
improved comfort, improved patient compliance
Reduced rate of rise of drug concentration
in blood. Thus, reduced side effects
To achieve a targeted drug release