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THE GASTROINTESTINAL SYSTEM: WATER AND ELECTROLYTE SYSTEM (1) Na, K ATPase…
THE GASTROINTESTINAL SYSTEM: WATER AND ELECTROLYTE SYSTEM
Water Absorption
Additional 0.5L per day in colon
Takes place in small intestine
1)
Na, K ATPase
consists of
enterocyte in small intestine and colonocytes
epithelial cells on luminal surface of colon
Process of absorption
creates Na electrochemical gradient
between
enterocyte
lumen
In small intestine
fraction of Na absorption takes place
through
organic solute uptake
SGLT (Sodium-glucose transport proteins
Na+ amino acid transporter
2)
Na coupled Transport
gradient created by Na, K ATPase
allows Na+ coupled transport from lumen to cell.
3)
NaCl co-transport is mediated by 2 transport proteins
Na/H (cation) works with HCO3/Cl (anion) exchange
to allow NaCl absorption
4)
Chloride secretion occurs in conjunction with basolateral Na, K, Cl transport
Na, K ATPase drives Na gradient further apart.
allowing Cl secretion through apical CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) channel
5)
Water follows Nacl
Water will travel through
intercellular tight junctions
in the setting of NaCl absorption