Please enable JavaScript.
Coggle requires JavaScript to display documents.
Li, Sophie_Block 2_MM10 (Initiation (start that the origins of…
Li, Sophie_Block 2_MM10
Initiation
start that the origins of replication
compose of 9 mer and 13 mer
9 mer is composed of mainly cytosine and guanine and the two is connected by a triple, making their connection stronger
13 mer is composed of mainly adenine and thymine, which form weaker, double bond, making it easier to separate
DNA polymerase called DNAa and DNAb binds between 9 mer and 13 mer, and assist in separating and unwinding the DNA strand at the 13 mer
A replication bubble forms, where the replication starts
SSB protein binds to the single strand DNA to prevent it from reaanealing and making the replication bubble more stable
elongation starts at the replication fork, which is a Y shaped region at the ends of the replication bubble.
Elongation
where the replication takes place in replication bubble.
bidirectional
leading strand
DNA pol III elongates the top strand in the 5'to 3' direction by adding nucleotides
primase attatches and create a single RNA primer at which the DNA pol III is going to start elongation at the 5' end of leading strand
DNA pol I removed the primer and replace with DNA segment
DNA ligase combines the primer DNA with the rest of DNA
lagging strand
DNA pol III elongates the bottom strand in the 3" to 5' direction by adding short DNA segments called Okazaki segments that grow in the 5'to 3' direction
DNA ligase come in between these short segments and joins them together
DNA pol I removed primer and DNA ligase joins the rest of DNA
the replication start at primer created by primase
DNA polymerase proofreads DNA
Termination
DNA stops replication at ter site located on the primer
DNA pol III falls off
when the replication fork meets ter site, replication ends
telomerase represents the end of a segment, can be identified through the reading of nucleotides.
have ten ter sites