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Industrial Chemicals (Aromatic amines (Carcinogenic aromatic amine (2…

- - - - 7-(2-oxyethyl)guanine / 7OEG
      - 3,N4-ethenocytosine
      - 1,N6-ethenoadenine
      - N2,3-ethenoguanine
      - All these are Nucleic acid adducts
      - Rearrangement
        
        Chloroacetaldehyde - reactive metabolite
    - - Respiratory irritation
      - Dizzy/sleepiness
      - Wheezing
      - Numbness of skin
      - Headache
    - - Severe lesion (necrosis, cell deaths)
      - Liver, lung or kidney impairment
    - - Liver cancer
      - Brain cancer
      - Lung cancer
      - Lymphatic malignancy
- - - - Antioxidant to maintain pliability of product
    - - Anti-rust
  - - - Form DNA adduct
        
        Cancer :no_entry:
        
        Due to nitrenium ion
        
        formed under acidic pH
    - - Tissue binding
        
        Cytotoxicity :warning: (less toxic than hydroxy)
    - - refer to above
- - - - White asbestos, known as chrysotile
  - - - Breathlessness
      - Fibrosis of the lung
      - Impaired lung function
      - Benign pleural disease
      - Bronchial carcinoma
      - Malignant mesothelioma - cancer of the pleural layer of lungs
- - - - CNS, GI (n&v), Metabolic (elevated osmolol gap)
    - - CVS, Pulmonary, metabolic (acidosis with elevated anion gap and reduce osmolol gap)
    - - Renal
      - Metabolic (normal anion and osmolol gaps)
      - Death
  - - - Can be stopped by fomepizole
        
        Inhibit alcohol dehydrogenase
        
        but has to be administered fast enough
    - - Cause acidosis
    - - into oxalic acid
        
        promote formation of crystal in kidney, lower kidney function