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Replacement Liver Function (hepamate (Porcine liver cells (remove toxic…
Replacement Liver Function
Cells
Stellate
Hepatocyte
Kuppfer
Pit Cells
Pathways
Urea
remove ammonia
Bile
Uptake
Metabolise
UDP
Transport
BMG
machines
Mechanical functionnot synthesis
hybrid
acinus
blood flow is unidirectional
portal vein
100-130 ml/min/100g
Function
Energy
Endocrine
Blood
hepamate
patients in intensive care
Charcoal filter
Porcine liver cells
remove toxic compound
make proteins
but need to prevent antgens from entering body
Are there sufficient cells
Sufficient oxygen
Function test
Meg-X
Cytochrome 450
metabolic activity
lidocaine
paracetomol
NAPQI which is toxic