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Alginates (Applications (Tissue engineering (Scaffolds (macroporous, Mimic…
Alginates
Applications
Delivery
Tissue engineering
Scaffolds
macroporous
Mimic damaged tissue
Optimissing porosity key to performance
altered by manufatcture
injectables
Wound dressing
Structure
G M blocks and MG blocks
More G more mechanically robust
High G gives high molecular weight
High molecular weight => Viscosity
Hydrogel
3d structure
hydrophillic
Cross linked
high water content
attractive
cells can remain vuiable in these structures
can be injected in to the body
Productions
Ionic cross Linking
Cross linker
Cross link concentration
Agitation level
Temperature
Biocompatibility
Inert
Doesnt provide binding sites
Need
RGD
Arganine
Glycine
Aspartic Acid
Degradeability
algiinase
dependent on molecular weight
Source
Process
Milling
extract
Dilute
purification
3 d printing