Please enable JavaScript.
Coggle requires JavaScript to display documents.
Path - Amyloid (i) (intro (appearance (on H+E (amorphous (undefined shape)…
Path - Amyloid (i)
intro
-
-
misfolded proteins aggregate to cytotoxic circulating oligomers, which polymerise to fibrils (insoluble aggregates)
-
specific precursor protein (over 30 types in various diseases, hereditary/non-hereditary, localised/systemic) misfolds to be linear in convoluted network of beta-pleated sheets instead of tertiary
-
-
-
Dx = histological
-
light microscopy, H+E, congo red (most important dx tool)
-
progressive accumulation - PRESSURE ATROPHY of adjacent cells, pushes cells apart
found in lamina proper (non-epithelial layer under epithelium - has blood vessels, inflamm cells + Ns)
-
late presentation with systemic amyloidosis - poor prognosis (death 1-3 yrs after Dx, depending on control of underlying condition)
-
Presentation
-
-
-
-
liver: increased LFTs, heaptomegaly
-
-
Classification
systemic
-
-
multiple myeloma, chronic inflamm conditions, chronic renal failure
localised
-
Alz, type 2 DM, prion disease of CNS
-
-
-
-