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Dermis Pathology (Vascular Neoplasm (Bacillary angiomatosis (Infectious…
Dermis Pathology
Vascular Neoplasm
Pyogenic granuloma
Lobular capillary proliferation
Mixed inflammatory infiltrate
Can ulcer and crust
Bacillary angiomatosis
Infectious agent at play
Single or multiple papule
Associated with AIDS
Neutrophil infiltrate
Positive wartin starry stain
Cherry hemangioma
Single or multiple papule
Negative WS stain
Can happen anywhere on body
Benign proliferation of capillaries
Cystic hygroma
Lymphangioma of the neck
Associated with Turner syndrome
Lymphatics NOT blood vessels
Glomus tumor
Benign
Painful red/blue tumor under fingernails
Arises from SM cells of thermoregulatory gloms body
Strawberry hemangioma
Benign proliferation of capillaries
Appears in first few weeks of life- regresses by age 5-8
No inflammatory cells
Negative WS stain
Kaposi sarcoma
Malignant vascular tumor
Affects skin, mouth, GI, respiratory system
Associated with HHV-8 and HIV
Lymphatic infiltrate
Angiosarcoma
Malignant vascular tumor
Risk factors
Eldery
Sun exposed
Lymphedema
Arsenic exposure
Aggressive
Follicular Neoplasm
Trichilemmoma
Multiple flesh colored papules
PTEN mutations (Cowden's)
INC risk for female cancers
Histology
Palasading
Pushing border
Eccrine/Aprocrine Neoplasm
Cylindroma
Clinical
Large dome shaped nodules
"turban tumor"
Brooke-Spielgler Syndrome
CYLD mutation
Histology
Jigsaw pattern
Multiple irregular tumor islands
Thick hyaline deposit
Two populations
Small cell with hyper chromatic nucleus
Large cells with open nuclei in the center
Sebaceous Neoplasm
Sebaceous Adenoma
Clinical
Yellowish papule
Associated with Lynch/ Muir Torre Syndrome
Histology
Well circumscribed
Lobulated
Sebaceous cells lined by basaloid cells