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Inflammatory Dermatosis (Bullous Dermatitis (Pemphigus Vulgaris and…
Inflammatory Dermatosis
Lichenoid Dermatitis
Lichen planus
Lymphocytic attack of dermal/epidermal junction
6 P's
Pruritic
Purple
Polygonal
Papules
Plaques
Wickham striae
Histopathology
Lichenoid lymphocytic infiltration
Epidermal hyperplasia
Hypergranulosis
Keratinocytes attacked and bleed melanin
Colloid bodies (cells that have died)
Erythema Multiforme
Annular plaques
Civatte Bodies
Lichenoid infiltrate is more sparse
Lots of narcotic keratinocytes
SJS/TENS
Lichenoid dermatitis with necrotic keratinocytes (Civatte bodies)
Drug induced
Defined by mucosal involvement and body surface involvement
DERM EMERGENCY
Full epidermal thickness necrosis
Psoriasiform Dermatitis
Psoriasis
Clinical
Well demarcated silver plaques
30% have nail changes
Histology
Psoriasiform hyperplasia
Wafer like scale with neutrophils
Loss of granular layer
Thinning of suprapapillary plates
Dilated blood vessels
Lichen Simplex Chronicus
Bullous Dermatitis
Pemphigus Vulgaris and Foliaceus
Superficial/ flaccid vesicle that ruptures easily
Shallow/ crusted erosions
Tombstoning
Net like IF pattern due to IgG to desmoglein
Bullous Pemphigoid
Tense bullae
Older individuals
Eubepidermal blister with eosinophils
IgG to hemidesmosomes and pemphigoid antigen
Dermatitis Herpetiformis
Pruritic papules on erythematous base
Associated with Celiac
AB to gliadin
Granular IF
Huge vesicle on erythematous base
Direct IF to classify
Classify by level of split and inflammatory cells present
Spongiotic Dermatitis
Keratinocytes being pulled apart by edema
Allergic contact dermatitis