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Pituitary hormone drugs (Growth hormone antagonists: bromocriptine…
Pituitary hormone drugs
Growth hormone agonists: somatropin (nutropin, saizen, humatrope)
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Mechanism of action: replace human growth hormone and stimulate skeletal growth, growth of internal organs and proteinsynthesis.
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contraindications:
abdominal surgery and acute illness secondary to complications of open heart surgery, potential problems with healing
pregnancy or lactation, potential adverse effect on fetus
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routr of admission: intramascularly, subcutaneous
Growth hormone antagonists: bromocriptine (parlodel), lantreolide (somatuline depot) octreotide(sandostatin), pegvisomant (somavert),
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mechanism of action
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octreotide and lanreotide are somastatin analogues which are potent in inhibiting GH release with less of an inhibitory effect on insulin
indications
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Treatment of Parkson,s disease
contraindications
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diabetes,thyroid dysfunction
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side effects
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Cardiovascular: sinus bradycardia,arrythmias
gastrointestinal: nausea and vomiting, abdominal cramps, constipation, diarrhea, acute cholecystitis, cholestatic jaundice, biliary tract obstruction
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other drugs chorionic gonadotropin (chorex), corticotropin(acthar), cosyntropin(cortrosyn), menotropin(pergonal), thyrotropin(thyrogen)
posterior pituitary hormone drugs: conivaptan(vaprisol), desmopressinDDAVP
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mechanism of action
cause cortical and medullary parts of the collecting duct to become permeable to water,
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Route of administration: oral, intravenous, subcutaneous and nasal
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side effects
abdominal cramps, flatulence, nausea and vomiting, constipation, dry mouth
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