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ADRENEGIC DRUGS (EPINEPHRINE (MECHANISM OF ACTION (Acts directly on Alpha…
ADRENEGIC DRUGS
EPINEPHRINE
INDICATIONS
Cardiac arrest (asystole, PEA, V-Fib, Pulseless V-Tach)
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Severe reactive airway disease (asthma, COPD)
NURSING CONSIDERATIONS
SIDE EFFECTS
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fast, slow, irregular, pounding, or racing heartbeat or pulse
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MECHANISM OF ACTION
Acts directly on Alpha & Beta receptors of the Sympathetic Nervous system. Beta effects are more profound than Alpha effects. Effects include:
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ISOPRENALINE
MECHANISM OF ACTION
Isoprenaline is a sympathomimetic that acts directly on β-adrenergic receptors. It stimulates the CNS, has powerful stimulating action on the heart, and has bronchodilating properties.
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NURSING CONSIDERATIONS
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STORAGE CONDITIONS
Store at controlled room temperature 20-25°C (68-77°F). Reconstituted solutions: To be used within 24 hr.
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SALBUTAMOL
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MECHANISM OF ACTION
Salbutamol activates adenyl cyclase, the enzyme that stimulates the production of cyclic adenosine-3', 5'-monophosphate (cAMP). Increased cAMP leads to activation of protein kinase A, which inhibits phosphorylation of myosin and lowers intracellular ionic Ca concentrations, resulting in smooth muscle relaxation.
SALMETEROL
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MECHANISM OF ACTION
Salmeterol stimulates intracellular adenyl cyclase, the enzyme that catalyses the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP) resulting in relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from mast cells.