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hormones and reproductive drugs (GONADOTROPHIN RELEASING HORMONE (…
hormones and reproductive drugs
OESTROGEN
MECHANISM OF ACTION
it inhibit the release of FSH by the negative feedback thus decreasing follicular development.
NURSING CONSIDERATION
STORAGE
store on room temperature
for tablets store in an air tight container
store away from sunlight
keep away from reach of children
ROUTE FOR ADMINISTRATION
Once orally
injectable
CONTRA INDICATION
pregnancy
liver disease
history of abnormal vaginal bleeding
circulation disorder
suspected breast cancer
migraine headache
SIDE EFFECTS
constipation, diarrhoea, vomiting
dizziness, depression, muscle weakness
weight loss or weight gain
swelling of the eyes, itching, difficulty in breathing
change in sexual desire, vaginal discharge, itching and irritation of vagina.
INDICATIONS
uterine bleeding
delayed puberty
ovarian failure
vasometer symptoms
GONADOTROPHIN RELEASING HORMONE ( LEUPROLIDE ACETATE)
INDICATIONS
Treat uterine fibriod
treat symptoms of endometriosis
treatment of prostate cancer
MECHANISM OF ACTION
leuprolide binds to the gonadotropin releasing hormone receptor and act as potent inhibitor of gonadotropin secretion
NURSING CONSIDERATION
SIDE EFFECT
night sweats
reduced sexual interest
redness, burning at injected site
vaginal bleeding
Vaginal discomfort, dryness and itching discharge
swollen ankles or feet
STORAGE
store in a refrigerator between 35.6 to 38 degrees Celsius and store in room temperature for up to 8 weeks once removed from refrigerator
CONTRA INDICATION
hypertensive patients
pregnancy and lactation
ROUTE FOR ADMINISTRATION
Intra muscular
NEXPLANO
NURSING CONSIDERATION
STORAGE
keep away from reach of children
Store away from direct sunlight
CONTRA INDICATIONS
progesterone dependant
pregnancy
Liver adenoma
severe impairment of liver function
unexplained vaginal bleeding
INDICATIONS
Its used for contraception
SIDE EFFECTS
mastalgia
weight gain
acne
breast pain
loss of libido
nausea
vomiting
dizziness
ROUTE FOR ADMINISTRATION
Subdermal
MECHANISM OF ACTION
It inhibits ovulation. it also thickens cervical mucus, inhibiting the passage of sperm to the uterus and thins the endometrium preventing implantation when fertilization took place