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The sulphonylureas (NAMES (Chlorpropamide, Glibenclamide, Gliclazide,…
The sulphonylureas
NAMES
Chlorpropamide
Glibenclamide
Gliclazide
Glimepiride
Glipizide
Gliquidone
Tolbutamine
NURSING CONSIDERATIONS
DM
DKA
Can be taken before breakfast
NSAID enhance effect
Thiazide diuretics reduce effect
SIDE EFFECTS
GIT upset
Fluid retention
Hypoglycaemia
Skin rashes
MECHANISM OF ACTION
Lower blood glucose level by increasing insulin production
INDICATIONS
Treatment of NIDDM in middle-aged & elderly who are obese
STORAGE INSTRUCTIONS
Room temperature
ROUTE OF ADMINISTRATION
orally