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Classification of Antimicrobials by Pharmacodynamic Properties (Inhibiting…
Classification of Antimicrobials by Pharmacodynamic Properties
Inhibiting Cell Wall Synthesis
Peniciliins
Cephalosporins
Bacitracin
Vancomycin
Prevent the synthesis of peptidoglycan by inhibiting transcriptase
Inhibiting Protein Synthesis
Target bacterial 70S ribosomes
Prevent translation from RNA to protein in ribosomes that are unique to bacteria
Chloramphenicol
Erthromycin
Streptomycin
Tetracyclines
Inhibiting Nucleic Acid Synthesis
Interfere with DNA replication and transcription
Quinolones
Rifampicin
Ciprofloxacin
Injuring the Plasma Membrane by Changing Membrane Permeability
Antifungal drugs combine with membrane sterols
Polymixin B
Amphotericin B (Fungizone)
Nystatin
Inhibiting the Synthesis of Essential Metabolites
Antimetabolites compete with normal substrates for an enzyme. Suflanilamide competes with para-aminobenzoic acid (PABA), stopping the synthesis of folic acid.
Trimethoprim-sulfamethoxazole