Please enable JavaScript.
Coggle requires JavaScript to display documents.
Lung Cancer (Small Cell Carcinoma (Rb1 mutation is hallmark of SCC, PTEN…
Lung Cancer
Small Cell Carcinoma
-
PTEN mutation, FGFR1 amp, SOX-2 amp, SLIT, EPHA7 mut.
-
Small, blue scanty cytoplasm
-
Pathophysiology
-
S/S
-
-
-
Paraneoplastic: ADH, ACTH, Parathormone, calcitonin, carcinoid sign
-
pneumonia, abcess, collapse- tumour obstruction
-
-
Carcinogens
-
polonium 210, As, Ni, Cd, Cr
-
Irritants/ accelerators: phenols, formaldehyde, HCN
Other causes: Asbestos, (mesothelioma), chronic lung disease, occupation (radon), FH
Dx + Tx
Tx depends on histology and TMN score (4,3,1, I-IV).
Immunotherapy: Pd-1 inhib: Nivolumab, pembrolizumab
Ct, PET, MRI, bronchoscopy, cytology, biopsy.
EGFR mutation- erlotinib, geftinib
ALK inhib/ ROS1- crizotinib, ceretonib
Secondary intrathoracic malignancy: lung + pleura to breast, GI, ovary. Unknown primary therefore difficult diagnosis.
-
Asbestos
Diffuse interstitial fibrosis of lung due to inhalation and retention of asbestos. Coated in Fe rich proteins. 30/1m deaths.
Malignant mesothelioma
-
Males, SOB, weakness, fatigue, weight loss, fever sweating.
-
Pleurisy + effusion. Met spread to lymph hilum, pericardium, peritoneal cavity. CAn thick and adhere to chest wall.
Dx- occupation hx, Imaging.
-
Immunotherapy: Pd-1 inhib: Nivolumab, pembrolizumab
Compensation: State (IIDB), prev. employer via court.
indestructible fibres: Serpentine, amosite, crocidolite inc. potency^
Cumulative dose, 50 yrs latent.
-
Pancoast's Tumour
Mitosis, ptosis, anhidrosis
-
Met -> bone, brain, liver and ad glands.
-
-