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Antineoplastic drugs (Methotrexete (Mechanism of action (Dihydrofolate…
Antineoplastic drugs
Methotrexete
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Indications
Breast and bladder cancer, Squamous cell carcinoma of the head and neck, Brain tumours, Osteosorcoma
Contraindications
Contraindicated to patients with rheumatoid arthritis with alcoholic hepatic disease. It should be cautiously given to any patient with a personal or family history of hepatic disease or
Route of administration
Oral, Intraveneous, Intramuscular, Subcutenous
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Side effect
Blood in the urine, Passing black stools, Diarrheoa
Raltitrexed
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Side effect
Bleeding gums, nose bleeding, chills and headache, flu like symptoms
Fluorouracil
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Indications
Cancer of the digestive tract, breast cancer, carcinoma of the colon, rectum
Contraindications
Contraindicated to patients with liver disease , pregnant women, and to patients with thrombocytopenia
Side effect
Headache, upper respiratory infections, muscle soreness, common cold
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