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The Paradox of Model Organisms (Zon; (adopted zebrafish as a model…
The Paradox of Model Organisms
chose to use the simplest organisms
bacteria and bacteriophages
model organisms
Caenorhabditis elegans
Drosophila
Arabidopsis
zebrafish and rodents
E.coli
remains the organisms of choice for many scientists
serve as a crucial model to study diseases
Animal models
been extremely helpful in identifying specific genes or pathways implicated in particular human diseases
Zon;
adopted zebrafish as a model organism largely because fertilization occurs exogenously
argued that the zebrafish is as good as any other vertebrate model
animal models have helped to elucidate may of the pathways underpinning the more complex behavioural functions of higher mammals
Jerry Yin;
chose to use
Drosophila
to study the molecular mechanisms of learning and memory formation
the organisms is, "complex enough to have interesting behaviours in terms of learning, memory formation, addiction, aggression and social activities, but is simple eough to allow researchers to 'see' and 'discover' some of the basic logic
one of the most important discoveries in
Drosophila
regulates the expression of various genes in many cells, including neurons, enhancing long-term memory
reduced the complexity of the task in two ways:
focused on a few central molecular mechanisms
chose to use the simplest organisms