Pruritus (itch)

Definition

Aetiology

Primary (skin)

Secondary

Inflammation
Eczema (atopic)
Urticaria (hives)
Insect bites

Degenerative
Senile atrophy (older dry skin)

Infection/infestation
Scabies burrows
Dermatitis herpetiformis
Viral infections
Fungal infections

Diagnosis

Examination

Investigations

History

Dermatological
Is there a lesion or not? If not, likely secondary/systemic
Colour (erythema, pallor, jaundice)
Finger webs, wrists, groin buttocks (scabies)
wheals (urticaria), excoriations, lichenification (eczema)
blisters (dermatitis herpetiformis), flat papules (lichen planus)
Nodules, ulcers scarring

Autoimmune
Lichen planus

Drugs
Statins
ACE-I
Opiates
Antidepressants

Neoplastic
Liver
Lymphoma/leukaemia
Any carcinoma
CNS/spinal tumours

Metabolic
Fe deficiency
CKD
Liver disease

General
Pallor (anaemia), clubbing (malignancy)
Enlarged LNs, hepatomegaly (lymphoma)
Signs of hypo/hyperthyroidism

Abdominal
Liver disease (jaundice, spider naevi, hepatosplenomegaly)
Renal disease (oedema, pallor)
Masses, cachexia (malignancy)

Bloods
FBC (anaemia, infection), CRP (infection, inflammation),
U+Es (CRF), LFTs (CLD), TFTs (hypo/hyperthyroidism, glucose (DM)
Fe studies (ferritin)

Imaging
CXR, CT abdomen (masses)

Bedside
Obs (sats, RR, HR, BP, temp)

SH
Occupation, living arrangements, smoking, alcohol, diet

FH
Skin conditions
Systemic disease

DH
Drugs causing itch e.g. opiates, statins
Allergies

PMH
Known skin conditions
Atopy, psychiatric disorders
Known systemic disease e.g. DM, CLD, CKD

Site (generalised, localised), character (prickling/crawling/burning), radiation (how has it spread), associated (sensation change, rashes), timing (how long for, worsened?), exacerbating/relieving factors (creams etc), severity (ADLs e.g. disturbed sleep), anyone else itchy
Red flags - fever, weight loss, night sweats

Autoimmune
MS

Management

Primary skin disease

Secondary cause
Treat cause

Conservative
Information, advice, support
Self care advice (cleaning, transmission)
Referral if diagnosis unclear (dermatology)

Medical

Emollients
E.g. diprobase
MOA: soothes dry skin, reducing itch

Antihistamines
MOA: reduce histamine release,
reducing itch at night to aid sleep

A poorly localized, usually unpleasant
sensation which elicits a desire to scratch

Special tests
Patch testing (dermatitis)
Biopsy (dermatitis herpetiformis)

Endocrine
Pregnancy
Hypo/hyperthyroidism
Hyperparathyroidism
DM

Functional
OCD, other neuroses
Psychogenic pruritus
Schizophrenia

Vascular
Strokes

Idiopathic
Xerosis (dry skin)

Haematological
Polycythaemia vera
Haemachromatosis

Complications

Dermatological
Lichen simplex chronicus (thickened skin)
Infections (impetigo)

Psychological
Insomnia
Depression
Poor concentration
Reduced libido

Swabs
Skin scrapings