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Pathogen (Dendritic Cell takes up Ag and presents it on MHC I and II (DC…
Pathogen
Dendritic Cell takes up Ag and presents it on MHC I and II
DC migrates to the lymph node and presents the Ag to naive T cells in the paracortex via MHC II
CD4+ T cell activation and priming
CD4+ t cell acts on DC via CD40L (T cell) - CD40 (DC) interaction
CD4+ T cell stimulates activation of CD8+ T cell
CD8+ T cells use TCR to recognise Ag in the context of MHC I on infected cells
CD8+ T cells kill infected cells
Perforin & Granzymes
Fas-FasL interaction
Apoptosis
CD4+ T cell upregulates chemoattractant molecules
CD4+ T cell meets B cell
B cell Activated
Clonal expansion - production of germinal centre
AID induces somatic hypermutation leading to affinity maturation
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Class switch recombination
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Plasma cells
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Co-stimulation CD28 (T cell) - B7 (DC)
Cytokines produced by DC
Free Antigen
Lymph Node
Follicular Dendritic cells (FDCs)
FDCs present Antigen to Naive B cells
Some clonal proliferation and B cells migrate towards T cells - chemotaxis
IgM